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发表论文(Publication)

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发表论文(Publications)

Publications

(ORCID: 0000-0002-0779-1488)

Works @ DICP

(24) A Non-Covalent AIEgen for in situ Detection of Proteome Liquid-to-Solid Phase Separation in Live Cells. in submission.

(23) Yu, J.; Li, T.; Liu, Y.; Wang, X.; Zhang, J.*; Wang, X.; Shi, G.; Lou, J; Wang, L.; Wang, C. C.; Wang, L.*; Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress. EMBO J, 2020, e103841

(22) Hoelzel, C., Hu, H., Wolstenholme, C. H.; Karim, B. A.; Munson, K. T.; Jung, K. H.; Zhang, H.; Liu, Y.; Yennawar, H. P.; Asbury, J. B.; Li, X.*; Zhang, X.*; A General Strategy to Enhance DonorAcceptor Molecules Using Solvent-Excluding Substituents. Angew Chem Int Ed Engl, 2020, 59, 2-10. (Hot Paper)


Prior to DICP

2019

(21) Kim, S. H.; Liu, Y.; Hoelzel, C.; Zhang, X.*; Lee, T. H.*, Super-Resolution Optical Lithography with DNA. Nano Lett. 2019, 19, 9, 6035-6042.

(20) Jung, K. H.; Kim, S. F.; Liu, Y.; Zhang, X.*, A Fluorogenic AggTag Method Based on Halo- and SNAP-Tags to Simutaneously Detect Aggregation of Two Proteins in Live Cells. ChemBioChem. 2019, 20, 1078-1087.

(19) Liu, Y.; Fares, M.; Zhang, X.*, Monitoring Proteome Stress in Live Cells Using HaloTag-Based Fluorogenic Sensor. Book Chapter, Protein Misfolding Diseases, 2019, Page 171-182.

(18) Jung, K. H.; Fares, M.; Grainger, L. S.; Wolstenholme, C. H.; Hou, A.; Liu, Y.; Zhang, X.*, A SNAP-tag fluorogenic probe mimicking the chromophore of the red fluorescent protein Kaede. Org. Biomol. Chem., 2019, 17(7), 1906-1915.


2018

(17) Liu, Y.; Wolstenholme, C. H.; Carter, G. C.; Liu, H.; Hu, H.; Grainger, L. S.; Miao, K; Fares, M;Hoelzel, C. A.; Yennawar, H. P.; Ning, G.; Du, M.; Bai, L.; Li, X.; Zhang, X.*, Modulation of Fluorescent Protein Chromophores to Detect Protein Aggregation with Turn-on Fluorescence. J. Am. Chem. Soc., 2018, 140(24), 7381-7384. (Highlighted by F1000Prime)

(16) Liu, Y.; Zhang, X.*, Heat Shock Protein Reports on Proteome Stress, Biotechnol. J., 2018, 13, 1800039.

(15) Liu, Y.; Miao, K; Li, Y; Fares, M; Chen, S; Zhang, X.*, A HaloTag-Based Multicolor Fluorogenic Sensor Visualizes and Quantifies Proteome Stress in Live Cells Using Solvatochromic and Molecular Rotor-Based Fluorophores. Biochemistry, 2018, 57, 31, 4663-4674.

(14) Fares, M.; Li, Y.; Liu, Y.; Miao, K.; Gao, Z.; Zhai, Y.; Zhang, X.*, A molecular rotor-based Halo-tag ligand enables a fluorogenic proteome stress sensor to detect protein misfolding in mildly stressed proteome. Bioconjugate Chem. , 2018, 29 (1), pp 215–224.


2017

(13) Liu, Y.; Miao, K.; Dunham, N. P.; Liu, H.; Fares, M.; Boal, A. K.; Li, X.; Zhang, X.*, The Cation-pi Interaction Enables a Halo-Tag Fluorogenic Probe for Fast No-Wash Live Cell Imaging and Gel-Free Protein Quantification. Biochemistry, 2017, 56 (11), 1585-1595. (ACS Editor’s Choice)

(12) Liu, Y.; Fares, M.; Dunham, N. P.; Gao, Z.; Miao, K.; Jiang, X.; Bollinger, S. S.; Boal, A. K.; Zhang, X.*, AgHalo: A Facile Fluorogenic Sensor to Detect Drug Induced Proteome Stress. Angew Chem Int Ed Engl, 2017, 56, 8672-8676. (Highlighted by F1000Prime).


2016

(11) Chen, W.; Kong, L.; Connelly, S.; Dendle, J. M.; Liu, Y.; Wilson, I. A.; Powers, E. T.*; Kelly, J. W.*, Stabilizing the CH2 Domain of an Antibody by Engineering in an Enhanced Aromatic Sequon. ACS Chem. Biol., 2016, 11 (7), 1852-61.

(10) Chen, W.; Dong, J.; Plate, L.; Mortenson, D. E.; Brighty, G. J.; Li, S.; Liu, Y.; Galmozzi, A.; Lee, P. S.; Hulce, J. J.; Cravatt, B. F.; Saez, E.; Powers, E. T.; Wilson, I. A.; Sharpless, K. B.*; Kelly, J. W.*, Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue. J. Am. Chem. Soc., 2016, 138 (23), 7353-64.

(9) Chen, W.; Dong, J.; Li, S.; Liu, Y.; Wang, Y.; Yoon, L.; Wu, P.; Sharpless, K. B.*; Kelly, J. W.*, Synthesis of Sulfotyrosine-Containing Peptides by Incorporating Fluorosulfated Tyrosine Using an Fmoc-Based Solid-Phase Strategy. Angew Chem Int Ed Engl, 2016, 55 (5), 1835-8.


2015

(8) Liu, Y.; Zhang, X.; Chen, W.; Tan, Y. L.; Kelly, J. W.*, Fluorescence Turn-On Folding Sensor To Monitor Proteome Stress in Live Cells. J. Am. Chem. Soc., 2015, 137 (35), 11303-11.

(7) Cho, Y.; Zhang, X.; Pobre, K. F.; Liu, Y.; Powers, D. L.; Kelly, J. W.; Gierasch, L. M.*; Powers, E. T.*, Individual and collective contributions of chaperoning and degradation to protein homeostasis in E. coli. Cell reports, 2015, 11 (2), 321-33.

(6) Baranczak, A.; Liu, Y.; Connelly, S.; Du, W. G.; Greiner, E. R.; Genereux, J. C.; Wiseman, R. L.; Eisele, Y. S.; Bradbury, N. C.; Dong, J.; Noodleman, L.; Sharpless, K. B.; Wilson, I. A.; Encalada, S. E.*; Kelly, J. W.*, A fluorogenic aryl fluorosulfate for intraorganellar transthyretin imaging in living cells and in Caenorhabditis elegans. J. Am. Chem. Soc., 2015, 137 (23), 7404-14.


2014

(5) Zhang, X.; Liu, Y.; Genereux, J. C.; Nolan, C.; Singh, M.; Kelly, J. W.*, Heat-shock response transcriptional program enables high-yield and high-quality recombinant protein production in Escherichia coli. ACS Chem. Biol., 2014, 9 (9), 1945-9; 1. (ACS Editor’s Choice, highlighted in C&EN News, and ACS Chem. Biol.).

(4) Liu, Y.; Zhang, X.; Tan, Y. L.; Bhabha, G.; Ekiert, D. C.; Kipnis, Y.; Bjelic, S.; Baker, D.; Kelly, J. W.*, De novo-designed enzymes as small-molecule-regulated fluorescence imaging tags and fluorescent reporters. J. Am. Chem. Soc., 2014, 136 (38), 13102-5.

(3) Liu, Y.; Tan, Y. L.; Zhang, X.*; Bhabha, G.; Ekiert, D. C.; Genereux, J. C.; Cho, Y.; Kipnis, Y.; Bjelic, S.; Baker, D.; Kelly, J. W.*, Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts. Proc. Natl. Acad. Sci. U.S.A., 2014, 111 (12), 4449-54. (highlighted in ACS Chem. Biol.)


2013

(2) Baranczak, A.; Connelly, S.; Liu, Y.; Choi, S.; Grimster, N. P.; Powers, E. T.; Wilson, I. A.; Kelly, J. W.*, Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging--what we know and what we need to learn. Biopolymers, 2014, 101 (5), 484-95.

(1) Suh, E. H; Liu, Y.; Connelly, S.; Genereux, J. C.; Wilson, I. A.; Kelly, J. W.*, Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis. J. Am. Chem. Soc., 2013, 135 (47), 17869-80.


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