研究方向 (Research Area)
Chemical Biology of Protein Conformational Diseases
Proteins need to fold into 3-dimentional structures to achieve their physiological functions. However, aberrant protein misfolding and aggregation lead to various protein conformational diseases, such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and cardiac amyloidosis etc. Limited tools that work in live cells are available for the field to visualize the entire process of protein aggregation and dissect the pathogenic misfolded states.
Our lab is specialized in fine tuning fluorescence properties (intensity, wavelength, lifetime etc.) of chromophores towards differentiating protein misfolded states. We are particularly interested in understanding how protein misfolds and aggregates into pathogenic states during liquid-liquid and liquid-solid phase separations. We are developing fluorescent and chemical probes that can be easily used by other groups to detect protein aggregation in live cells. Currently our lab works on three major projects:
1. Development of imaging toolbox to resolve protein misfolding and aggregation states during protein phase separation.
2. Development of high throughput methods for early diagnosis and drug screening.
3. Development of chemical probes to dissect drug target engagement.