About us

Proteome misfolding and aggregation generally occur upon proteostasis network deterioration, causing numerous diseases, including neuromuscular degeneration, metabolic disorders, and certain types of cancers. The overarching goal of our lab is to develop analytical tools and methods to visualize and dissect aggregated proteome in live cells. Fluorescent sensors developed by our lab can report on the localization, morphology, and compactness of aggregated proteome. Together with proteomics collaborators, we developed chemical proteomics method enabling in-situ analysis of the contents of aggregated proteome with spatial and temporal resolution.